2022-RA-872-ESGO Percutaneous uterine needle biopsy with microscopic and array-CGH analyses in patients with suspicious myometrial tumors on MRI: a prospective study

Introduction/Background Preoperative diagnosis of uterine tumors is utmost importance to avoid inadvertent morcellation leiomyosarcoma (LMS) and unnecessary hysterectomy in childbearing patients. There are no pathognomonic criteria for malignancy on Magnetic Resonance Imaging (MRI). The includes microscopic genomic analyses with array-Comparative Genomic Hybridization (CGH). To date, study has evaluated preoperative percutaneous needle biopsy (PUB) examination (M-PUB) array-CGH (MCGH-PUB). Methodology This a prospective single-center cohort including all consecutive patients who had LMS suspicion MRI whom PUB was performed. Microscopic index (GI) count myometrial were performed order guide the therapeutic strategy. Smooth muscle uncertain potential (STUMPs) GI superior 15 assessed malignant, as well complex profile (GI 30 and/or malignant profile). diagnoses based M-PUB MCGH-PUB compared postsurgical pathological specimen or follow-up non-operated tumors. Results From November 2016 February 2022, 34 included. Based surgical (n=23) follow up (n=11, 4 metastasis), final were: 11 sarcomas 23 non-sarcomas 22 LM one inflammatory myofibroblastic tumor[JS1] . median 12 months (IQR: 6–37). diagnostic accuracy 94% 100%. sensitivity, specificity Negative Predictive Value 100%, 100% A high significantly associated (p<0·001). allowed correct upgrade four after suspicious examination. complication dissemination track. Conclusion safe accurate discriminate pre operatively benign from sarcoma.